Peer-Reviewed Medical Research

Advancing Healthcare Through Open Science

Journal Of International Square MedTech publishes rigorous, peer-reviewed research in medical technology, clinical innovation, and health sciences — fully open access.

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Cardiology Medical Technology
⬡ Open Access
Machine Learning Models for Predicting Cardiovascular Risk in Type 2 Diabetic Patients: A Multi-Center Study

This study evaluates the predictive accuracy of five machine learning algorithms — random forest, XGBoost, SVM, neural network, and logistic regression — applied to a dataset of 12,400 patients across three tertiary care hospitals in Bangladesh. Results demonstrate that ensemble methods significantly outperform traditional scoring systems in 5-year cardiovascular risk prediction.

Neurology
⬡ Open Access
Resting-State fMRI Biomarkers for Early Alzheimer's Disease Diagnosis: A Systematic Review and Meta-Analysis

We conducted a systematic review of 47 studies (n = 8,320) investigating resting-state functional connectivity as a diagnostic biomarker for Alzheimer's disease. Pooled analysis reveals default mode network disruption exhibits 84% sensitivity and 79% specificity in pre-symptomatic detection, supporting its integration into clinical screening protocols.

Oncology Immunotherapy
⬡ Open Access
Checkpoint Inhibitor Efficacy in PD-L1 High Expression Non-Small Cell Lung Carcinoma: Real-World Evidence from Dhaka Medical College

A retrospective cohort study of 218 NSCLC patients with PD-L1 ≥50% tumor proportion score treated with pembrolizumab monotherapy. Median progression-free survival of 11.2 months (95% CI 9.4–13.8) was observed, consistent with global trial data. Drug access barriers unique to the South Asian context are discussed.

Surgery
⬡ Open Access
Laparoscopic vs. Open Cholecystectomy in Acute Cholecystitis: Comparative Outcomes in Resource-Limited Settings

Prospective randomized trial comparing laparoscopic (n=145) versus open (n=141) cholecystectomy in patients presenting within 72 hours of acute cholecystitis onset. Laparoscopic approach demonstrated significant reductions in hospital stay (2.1 vs 5.4 days) and postoperative complications without significant difference in operative time.